Serotonin depletion with P-chlorophenylalanine in the cat: effects on carbachol-induced defensive behavior and regional brain amine content.

Depletion of Serotonin Synthesis with p-CPA Pretreatment Alters EEG in Urethane Anesthetized Rats under Whole Body Hyperthermia

Serotonin is believed as an important factor in brain function. The role of serotonin in cerebral psycho-patho-physiology has already been well established. However, the function of serotonin antagonist in anesthetized subjects under hyperthermia has not been studied properly. Methods: Experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control group, (ii) wh...

Effect of Prenatal Stress and Serotonin Depletion on Postnatal Serotonin Metabolism in Wistar Rats

Prenatal stress in rats results in structural, physiological and behavioral alterations that persist in adulthood. Serotonin (5-HT) is an important neurotransmitter known to be involved in these prenatal stress-induced behavioral alterations. The aim of the study was to investigate the effects of interrupted synthesis of 5-HT and immobilization stress during different gestational period on brai...

Brain serotonin depletion enhances the sodium appetite induced by sodium depletion or beta-adrenergic stimulation.

We investigate the influence of brain serotonin depletion on the sodium appetite. Rats depleted of serotonin through the systemic administration of p-chlorophenylalanine (300 mg/kg, ip, for 2 days) showed an intense natriorexigenic response induced by sodium depletion (furosemide, 20 mg/kg, sc, 24 h before water and 1.8% NaCl presentation). Intake of 1.8% NaCl was always higher than that observ...

The participation of serotoninergic system in the regulation of emotional-defensive behavior evoked by intrahypothalamic carbachol injections in the cat.

The influence of bilateral injections of serotonin (5-HT) and methysergide (MET) to antero-medial hypothalamus (HA) on carbachol-induced emotional-defensive behavior was investigated. Earlier (15 min) stimulation of 5-HT receptors in HA region by 5-HT injections evoked a decrease in the level of vocal response (number and time of growling), while previous blocking of these receptors by means of...

Serotonin in Brain Behavior: Drug-Induced Alterations Para-chlorophenylalanine Behavior: Neurochemically-induced Alterations Behavioral Assessment and Control Schedule-dependent Drug Effects Influence of Behavior on Transmitter